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Distinguished Professor

Chen, Shu-Hui

Analytical Chemistry, Mass Spectrometry
Separation Science, Proteomics
Biochemical Analysis

✉ Email：shchen@mail.ncku.edu.tw       ☎ Phone：06-2757575-65339

Education

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BS in Chemistry, National Tsing Hua University (1983)

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MS in Chemistry, National Taiwan University (1986)

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PhD in Chemistry, Michigan State University (1993)

Experience

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1983-1984  National Tsing Hua University, Assistant

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1996-2000  National Cheng Kung University, Associate Professor

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2000-Present  National Cheng Kung University, Professor

Publications

  1. Akbarian, M.; Chen, I. N.; Lu, P. H.; Do, Q. T.; Tzeng, S. F.; Chou, H. H.; & Chen, S. H.* “Chaperone/Polymer Complexation of Protein-Based Fluorescent Nanoclusters against Silica Encapsulation-Induced Physicochemical Stresses.” Biomacromolecules, 2024 25 (10), 6515-6525

  2. Kuo, C.M.; Jen, H.H.; Chen, F.Y.; Akbarian, M.; Ou, T.H.; Liu, K.Y.; Lin, J.L.; Chen, S.H.* "High-performance peptide and disulfide mapping by direct injection of intact proteins using on-line coupled UV-liquid chromatography microdroplet mass spectrometry (UVLC-MMS)" Analytica Chimica Acta, 2023, 1279, 341790.

  3. Akbarian, M.; Chen, S. H.*; "Instability challenges and stabilization strategies of pharmaceutical proteins." Pharmaceutics, 2022, 14(11), 2533.

  4. Kafeenah, H.; Kuo, C.M.; Chang, T.Y.; Jen, H.H.; Yang, J.H.; Shen, YS.; Wu, C.H.; Chen, S.H.*"Label-free and de-conjugation-free workflow to simultaneously quantify trace amount of free /conjugated and protein-bound estrogen metabolites in human serum" Analytica Chimica Acta, 2022, 1232, 340457.

  5. Akbarian, M.; Chen, S. H.; Kianpour, M.; Farjadian, F.; Tayebi, L.; Uversky, V. N.; "A review on biofilms and the currently available antibiofilm approaches: Matrix-destabilizing hydrolases and anti-bacterial peptides as promising candidates for the food industries" Int. J. Biol. Macromol. 2022, 219, 1163–1179.

  6. Akbarian, M.*; Bahmani, M.; Chen, S.H.; Yousefi, R.; Mohammadi-Samani, S.; Tayebi, L.; Panahi, F.; Farjadian, F.*"Mechanisms behind the Fibrillation and Toxicity of Insulin Fibrils on Neuron Cells by Engineered Curcumin Analogs" ACS Chem. Neurosci., 2022, 13, 17, 2613–2631.

  7. Huang, W.C.; Huang, L.J.; Hsu, L.S.; Huang, S.T.; Lo, W.T.; Wang, T.F.; Sun, W.T.; Wei, W.Y.; Lee, Y.S.; Chuang, S.H.; Lee, C.P.; Chou, H.H.*; Chen, S.H.* "Selective and predicable amine conjugation sites by kinetic characterization under excess reagents" Scientific Reports, 2021, 11, 21222.

  8. Jen, H.H. ; Kafeenah, H.; Chang, T.Y. ; Lin, Y.M. ; Shan, Y.S. ; Wu, C.H.; Chen, S. H.* "Quantification of the Endogenous Adduction Level on Hemoglobin and Correlation with Albumin Adduction via Proteomics: Multiple Exposure Markers of Catechol Estrogen" J. Proteome Res., 2021, 20, 9, 4248–4257.

  9. Wang, S.A.; Young, M.J.; Wang, Y.C.; Chen, S.H.; Lo, Y.A.; Jen, H.H.; Hsu, K.C.; Hung, J.J.* "USP24 promotes drug resistance during cancer therapy" Cell Death Differ., 2021, 28, 2690-2707.

  10. Kuo, C.M.;Wei, S.Y. ;Du, S.H. ;Lin, J.L. ;Chu, C.H. ;Chen, C.H.;Tai, J.H. ; Chen, S. H. * "Comprehensive Workflow for Mapping Disulfide Linkages Including Free Thiols and Error Checking by On-Line UV-Induced Precolumn Reduction and Spiked Control" Anal. Chem., 2021, 93, 3, 1544-1552.

  11. Do, Q.T. ; Huang, T.E. ; Liu, Y.C. ; Tai, J.H.; Chen, S. H. * "Identification of Cytosolic Protein Targets of Catechol Estrogens in Breast Cancer Cells Using a Click Chemistry-Based Workflow" J. Proteome Res., 2021, 20, 1, 624-633.

  12. Hsu, H. M.; Huang, Y. H.; Sarita Aryal; Liu, H. W.; Chinpan Chen; Chen, S. H.; Chu, C. H.*; Tai, J. H.* "Endomembrane Protein Trafficking Regulated by a TvCyP2 cyclophilin in the protozoan parasite, Trichomonas vaginalis" Sci. Rep., 2020, 10, 1275.

  13. Lin, H. S.; Yan Wu; Liu, Y. J.; Chen, S. H.*; Chen, W. T.*; Wang, S. P.* "Comments on chemical properties reported for diphenyl disulfide and its derivatives: The merit of the phenyl groups" J. Chin. Chem. Soc., 2019, 67, 324–328.

  14. Huang, Y. S.; Lin, Y. M.; Chen, Hsin; Wu, C. H.; Syu, C. H.; Huang, T. E.; Do, Q. T.; Chen, S. H.* "Targeting Endogenous Adduction Level of Serum Albumin by Parallel Reaction Monitoring via Standard Additions and Intact Protein Measurement: Biological Dosimetry of Catechol Estrogens" Anal. Chem., 2019, 91, 15922-15931.

  15. Hsu, Y. C.; Hung, M. J.; Chen, Y. A.; Wang, T. F.; Ou, Y. R.; Chen, S. H.* "Identifying Reducing and Capping Sites of Protein-Encapsulated Gold Nanoclusters" Molecules, 2019, 24, 1630.

  16. Huang, L. J.; Chiang, C. W.; Chen, S. L.; Wei,S. Y.; Chen, S. H.* "Complete mapping of disulfide linkages for etanercept products by multi-enzyme digestion coupled with LC-MS/MS using multi-fragmentations including CID and ETD" J. Food Drug Anal., 2019, 27, 531-541.

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