top of page
李彥君.jpeg

​李彥君

 

​助理教授​

有機化學、化學生物學​

✉ 信箱：yenchunlee.chem@gmail.com; 

        ycl_lab@gs.ncku.edu.tw

☎ 電話：06-2757575-65327

學歷

Unknown-3.png

國立清華大學  化學  學士 (2008)

Unknown-3.png

國立清華大學  化學  碩士 (2010)

tu.jpg

德國多特蒙德科技大學 化學生物學 博士 (2018)

​經歷

MIT.png

2019-2021 麻省理工學院 博士後研究員

unnamed.jpg

2021-迄今 國立成功大學 化學系 助理教授

著作

  1. Callahan, A. J., Gandhesiri, S., Travaline, T. L., Reja, R. M., Lozano Salazar, L., Hanna, S., Lee, Y.C.,  ... & Pentelute, B. L.* "Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins." Nature Communications, 2024, 15(1), 1813.

  2. Jimenez-Macias, J. L.; Lee, Y. C.; Miller, E.; Finkelberg, T.; Zdioruk, M.; Berger, G.; Lawler, S. E. "A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma" J. Control. Release 2022, 352, 623. 

  3. Ye, X.Y.*; Lee, Y.C.*; Gates, Z.P.; Ling, Y.J.; Mortensen, J.C.; Yang, F.S.; Lin, Y.S.; Pentelute, B.L.* " Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions" Communications Chemistry, 2022, 5, 128.

  4. Pomplun, S.; Jbara, M.; Quartararo, A.J.; Zhang, G.W.; Brown, J.S.; Lee, Y.C.; Ye, X.Y.; Hanna, S.; Pentelute, B.L.* " De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein" ACS Cent. Sci., 2021, 7, 1, 156-163.

  5. C. M. Fadzen; J. M. Wolfe; W. Zhou; C.-F. Cho; N. von Spreckelsen; K. T. Hutchinson; Y.-C. Lee; E. A. Chiocca; S. E. Lawler; O. H. Yilmaz; S. J. Lippard*; B. L. Pentelute* "A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain" J. Med. Chem. 2020, 63, 13, 6741-6747.

  6. Y.-C. Lee; L. Knauer; K. Louven; C. Golz; C. Strohmann; H. Waldmann*; K. Kumar* "Gold(I)‐catalyzed and Nucleophile‐guided Ligand‐directed Divergent Synthesis" Eur. J. Org. Chem. 2018, 41, 5688.

  7. Y.-C. Lee; K. Kumar* "Gold(I) catalyzed enyne cycloisomerization – a roadmap to privileged heterocyclic scaffolds" Isr. J. Chem. 2018, 58, 531.

  8. Y.-C. Lee; K. Kumar*; H. Waldmann* " Ligand-directed divergent synthesis of carbo- and heterocyclic ring systems" Angew. Chem. Int. Ed. 2018, 57, 5212.

  9. H.-R. Wu; Y.-C. Lee* "The synthetic approach and logic of design behind the small molecule compound library synthesis" Chemistry (Chinese Chemical Society, Taipei) 2017, 75, 267.

  10. P.-K. Tsou; Y.-C. Lee; T. Lankau; M. Isobe; C.-H. Yu* " Substituent effects in the Nicholas epimerization of glycosides" J. Phys. Org. Chem. 2017, e3780.

  11. Y.-C. Lee; S. Patil; C. Golz; C. Strohmann; S. Ziegler; K. Kumar*; H. Waldmann* " A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity" Nat. Commun. 2017, 8, 14043.

bottom of page